Protein Details: Pannexin-1

Protein ID

ICDB_Pro_1408

Protein Name

Pannexin-1

Gene Name

PANX1; MRS1; UNQ2529/PRO6028

Organism

Homo sapiens (Human)

Length

426 amino acids

AlphaFoldDB

AF-Q96RD7-F1-model_v4.pdb

Function

Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Plays a critical role in oogenesis.

Sequence

MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC

PDB Structures

6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Oocyte/Zygote/Embryo Maturation Arrest 7 and Female Infertility Due To Oocyte Meiotic Arrest

Location

Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).

DOI ID

RefSeq

NP_056183.2 [Q96RD7-1]